AbbVie Senior Scientist II, Tau in Cambridge, Massachusetts

The aggregation and propagation of the microtubule associated protein tau are key events in the pathophysiology of Alzheimer disease. The goal of the tau pathobiology group is to uncover biological mechanisms that underpin this fundamental pathological process and identify new treatments to prevent and/or slow down the neurodegeneration associated with Alzheimer’s disease. The tau pathobiology group has an opening for a Senior Scientist I/II position to support our current effort in characterizing the consequences of tau pathology on synaptic transmission at the functional and structural level. The successful candidate will conduct bench research using various imaging techniques relevant to neurodegenerative diseases.

Job responsibilities: * The successful candidate will have a deep knowledge in neuroscience with a particular focus on the mechanism of synaptic transmission.
* Expertise in immunohistochemistry of synaptic markers, fluorescence microscopy and image analysis is required. * Experience in mammalian cell culture, including primary neuronal culture, is required. * Practical experience with in vivo 2-photon microscopy and dendritic spine quantification would be an advantage. * Experience in neurodegenerative disease is preferred.

Basic: * PhD in Neuroscience with 4 years of academic or industry research experience; MS with 10 years of experience; or BS with 12 years of experience * Demonstrated ability to independently design, execute and interpret critical experiments to answer scientific questions. * The successful candidate must be highly collaborative, enjoying a dynamic, multi-disciplinary team environment.

Key Leadership Competencies: * Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance. * Learns fast, grasps the "essence" and can change course quickly where indicated. * Raises the bar and is never satisfied with the status quo. * Creates a learning environment, open to suggestions and experimentation for improvement. * Embraces the ideas of others, nurtures innovation and manages innovation to reality.

Job Classification: Experienced
Primary Location: USA-Massachusetts-Cambridge
Organization: Research & Development
Schedule: Full-time
Shift: Day
Travel: Yes, 5 % of the Time
Req ID: 1703018

Equal Opportunity Employer Minorities/Women/Veterans/Disabled