AstraZeneca Pharmaceuticals LP Project Leader/Senior Project Leader in Waltham, Massachusetts

Oncology Innovative Medicines and Early Development (IMED) Project Leader / Senior Project Leader

At AstraZeneca, we work together across global boundaries to make an impact and find answers to challenges. We do this with the utmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people’s exceptional skills with those of people from all over the globe.


The IMED Oncology has the accountability for all activities in small molecule oncology research up to the start of Phase III clinical studies. Within the IMED, leadership of projects occurs within the Oncology Projects Group with the head of this group reporting to the head of IMED Oncology. Project Leader/Senior Project Leader has the accountability for the strategy and execution of projects and lead cross-functional teams to deliver these objectives.

As the Project Leader/Senior Project Leader, you will lead the development and execution of the product strategy for one or more projects (which may be either clinical or pre-clinical). You will develop a range of strategic and tactical options, secure governance approval for the projects and then take accountability for execution, monitoring and reporting of progress / issues. You will be responsible for articulating the project goals, strategy and the underlying science and clinical need to internal and external audiences with clarity and credibility.

You will work in a highly effective way with other project leaders, scientific and clinical leaders and external opinion leaders to develop integrated plans which can be delivered across cross-functional boundaries. In this position, you must be able to demonstrate effective delivery through both internal groups or through external collaborative studies, with fee-for-service groups or through collaboration.

As the Project Leader/Senior Project Leader, you will be expected to demonstrate highly visible leadership within the Oncology community and to support the broader goals of the IMED Oncology. Development of clinical and non-clinical staff will be expected with the individual embodying the AstraZeneca values.

To be successful in this role you will need to be a strong leader who can demonstrate strategic thinking, ability to work collaboratively and act decisively. You will need a blend of late stage drug development experience coupled with a strong oncology background. This role will be based at our Boston/Waltham research site.


  • Key Deliverables

As a Project Leader/Senior Project Leader:

  • Lead projects from Lead Optimisation Investment Decision to PoP/PoC:

  • Responsible for project strategy, TPP and delivery.

  • Ensuring alignment with the project strategy to the disease area strategy.

  • Interfacing and positioning of project within the broader business context.

  • Pro-active in cross project and disease area learnings.

  • Ensure appropriate resourcing of the team.

  • Seek and apply best practices (internally and externally) in processes, data analysis, and decision-making in the project team.

  • Ensure that IP assets of the project are developed, managed and protected.

  • Ensure, together with functional leaders in and outside IMEDs, that the project team is appropriately resourced (number of FTEs and right talent), including exploration of externalisation opportunities; ensure resources from functions are managed effectively in the project team.

  • Ensure that there are robust processes, plans and data to enable Governance Bodies to make investment decisions and prioritise projects across the portfolio.

  • Accountable for the delivery of project according to quality, time, budgets and resources.

  • Culture

  • Create a vibrant, entrepreneurial and externally facing team focused on the delivery of successful PoCs that supports courageous leadership, innovation and collaboration, such that the Project team is open to challenge, new ideas, innovative ways of working, and where continuous learning and improvements are driven (development of talent).

  • Collaborate strongly with other IMED Project Leaders to embed best practice (collaboration & partnership).

  • Talent Management & Development

  • Provide high quality feedback and coaching to deployed reports and mentor key talent in the organization (development of talent).

  • Collaborate with VP Projects, Senior Project Leader and deployed functions to build outstanding project leadership within the IMEDs. (development of talent, collaboration & partnership).

  • External

  • Work with the VP Projects and Senior Project leader to ensure best practice for Project Leadership is identified and exploited within the team (science & innovation).


  • As a member of the IMED Projects Group

  • Support development of a winning disease area strategy, driving portfolio value. (sustainable portfolio).

  • Share responsibility for IMED Disease Area strategies, and the delivery of sufficient successful POP/POC, demonstrating therapeutic relevance, with high probability of successful market access and delivery of valuable new medicines (sustainable portfolio).

Minimum Requirements – Education and Experience


  • Advanced degree in life sciences, MD and/or PhD or equivalent.


  • Mastery level of project management in a pharmaceutical clinical discovery/development environment.

  • Experience of working with projects in discovery and development setting.

  • Experience of decision making and leadership in a cross-disciplinary/functional, cross-cultural environment.

  • Experience in either science, clinical or drug development.

  • Awareness of scientific as well as commercial/payer, regulatory and broader strategic aspects.

  • Experience of the working with the disease area.

  • Practical experience in working on teams in the discovery and development settings.

  • Strong project management expertise.

  • Proven leadership skills in managing projects.

  • Ideal candidate would have operational experience in risk management and contingency planning.

AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world’s most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.

Next Steps – Apply today!

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity. If you know someone who would be a great fit, please share this posting with them.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.