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Sanofi Group RNA Machine Learning Senior Scientist - Vaccine in Cambridge, Massachusetts

Position Overview:

The Scientific Digital Innovation (SDI) group is working to develop and deploy state-of-the-art digital strategies/solutions to meet Sanofi Pasteur's mission of being the disruptive market leader in vaccines. The SDI group seeks entrepreneurial and forward-thinking individuals to help drive RNA technologies and Machine Learning solutions to create value, improve efficiency and quality across the research and development pipeline.

S/he will have deep knowledge and experience in both machine learning and RNA Biology (structure, function, immunogenicity) and the ability to rapidly transform theory to actionable prototype. S/he will be responsible for developing machine learning and complex analytical workflows to support the selection, design and optimization of mRNA sequences and mRNA formulations. S/he will have a high degree of proficiency in Python/R, deep learning libraries, bioinformatics tools and cloud computing.

S/he will be ready to hit the ground running in a fast-paced environment that rewards personal initiative, collaboration, and scientific excellence.

Key Responsibilities:

  • Lead efforts to develop robust solutions for the design and optimization of mRNA vaccines.

  • Design and assess studies to evaluate the performance of mRNA designs. Transform experimental results into development and refinement of mRNA design and optimization algorithms.

  • Ability to switch smoothly between different scientific and operational disciplines and requirements; being able to marry deep scientific research and fast exploratory mindset with proper documentation.

  • Prototyping, optimizing and implementing machine learning and analytical models addressing complex biological questions.

  • Develops, deploys, and assesses the results of at-scale models at varying levels of model granularity encompassing heterogeneous preclinical and clinical data.

  • Designs and performs computational experiments with a ‘fail fast’ spirit and considers the outlier result the most interesting.

  • Meets with stakeholders and other group experts to translate biological and vaccine development scientific challenges into rigorous goals.

  • Maintains a well-documented, reusable codebase, and traceable model history.

  • Generates IP and participates in the drafting of patent filings.

Basic Qualifications:

  • Advanced degree in computational biology/molecular biology (RNA) with expertise in machine learning or an advanced degree in computational sciences, machine learning or other technical fields with expertise in RNA biology.

  • Deep knowledge and experience in RNA biology (structure, function, engineering).

  • Strong domain knowledge in machine learning (Deep Learning, Embeddings, Reinforcement and Transfer Learning) and algorithmic analysis of data.

  • High proficiency transforming algorithms/theory into practical applications delivering robust models that are high performance, interpretable and actionable.

  • Ability to navigate ambiguity and interact effectively with unconventional people and ideas. Work with partners across the organization to turn data into critical information and knowledge for improved process understanding to facilitate data driven decisions making.

  • A creative problem solver, skilled in divergent thinking and turning complex data into actionable insights and knowledge.

  • Excellent communication, scientific writing and presentation skills. Ability to develop and present results as visually appealing and understandable stories.

  • Understanding of ribosome profiling is a plus.

  • Understanding of drug/vaccine discovery and development processes is a plus.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

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