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Karyopharm Therapeutics Inc. Director, Total Rewards in Newton, Massachusetts

The Director of Global Compensation will ensure that Karyopharm’s compensation, equity, and other rewards programs are forward-thinking, competitive, support the delivery of our desired employee experience, and align with the Company’s culture and business strategy. To be successful in this role, you must be comfortable working in a purpose-driven, collaborative culture at both the strategic and tactical levels, thinking longer-term while rolling up your sleeves to execute the details.

As a Karyopharmer, reporting to the VP of Human Resources, you will positively impact patients’ lives by:

  • Leading the compensation and equity function to ensure programs such as broad-based compensation, equity, bonus programs, recognition, health are competitive, valued, and aligned with our business strategy.

  • Identifing and propose modifications and enhancements to our total reward programs to address our employees' changing needs and the competitive environment for talent in our industry.

  • Partnering with Head of Talent Acquisition on developing offers that are competitive and equitable. Provide guidance on total compensation and equity.

  • Supporting the Chief People Officer on executive compensation analyses and preparation of materials for the Compensation Committee of the Board of Directors.

  • Working alongside the team, develop and deliver communications that help our employees appreciate and value their total compensation package benefits, base, bonus, equity, time off, etc.); create total rewards statements and materials.

  • Collaborating with the HR Team and IT to identify technology and system needs that support a growing organization.

  • Driving both the year end focal and mid-year review process across the organization to align compensation, equity and bonus.

  • Remaining current on industry trends, best practices, compliance, new/progressive processes, etc., that enable Karyopharm to achieve higher organizational excellence levels.

You will rock this role if you bring:

  • BA/BS Degree in Human Resources, Business, or other relevant area is required

  • A minimum of 10 years of diverse experience and progressive responsibility in compensation and equity for a publicly traded organization, preferable within the life sciences industry.

  • Demonstrated ability to successfully execute in a high growth environment with limited infrastructure.

  • Possess both strategic capabilities with a “roll up your sleeves approach.” This is a leadership position in a small, growing company requiring hands-on execution.

  • Strong project management and prioritization skills to effectively manage and drive multiple projects and initiatives in a fast-paced environment.

  • Strong technical proficiency with HR systems and MS Office tools, including advanced Excel and PowerPoint skills required.

  • Understanding of and experience with equity plans and different types of equity vehicles for publicly traded companies.

  • Expert understanding of SEC, SOX, tax requirements, and all other government regulations apply to compensation, benefits, and equity.

Our Karyopharmers live and demonstrate our ICURE values every day!


Karyopharmers are passionately driven in our mission to positively impact patients’ lives and defeat cancer! This is personal, and we approach every challenge fiercely and tenaciously, but with enthusiasm, empathy, and passion. The work we do is both inspiring and life-changing. It requires the most diverse, the most unique, and the most authentic team in the industry. We are 400+ cancer driven conquerors, across the globe, with a strong sense of our values and our purpose. We are innovators, disrupters, and collaborators, and we challenge the norm and do things differently. At Karyopharm you will have the opportunity to do well by doing good, while learning and growing along the way. We invite you to join us and make your own personal contribution to our mission!

What We Offer:

In addition to our exciting, supportive, and intellectually challenging global workspaces(s), Karyopharmers enjoy a comprehensive and generous benefits package (active on day one) that makes them more productive and contributes directly to the development of their professional skills.

  • A fun, collaborative, work environment

  • A culture of employee engagement, diversity, and inclusion

  • Competitive salary, bonus, and generous equity offerings (Stock options and RSU’s-at time of offer and annual awards) – we are partners in prosperity!

  • Peace of mind through best in class medical (deducible paid by KPTI), dental, vision, disability, and life insurance, parental leave, a matching 401k program (immediate vesting), and tuition reimbursement.

  • Generous PTO and Holidays – we encourage you to recharge and spend time with family and friends.

  • Ample opportunities to learn and take on new responsibilities in a fast-paced, and patient focused company. (tuition reimbursement, management development programs, and a variety of reward and recognition programs)

  • Cell phone allowance

*Karyopharm requires all employees to be fully vaccinated against the Covid19 virus at the time of employment

This position maybe conducted under a hybrid work arrangment



ID: 2022-2007

Street: 85 Wells Ave.