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Karyopharm Therapeutics Inc. Senior IT Business Partner in Newton, Massachusetts

Karyopharm is looking for a Senior IT Business Partner to provide partnership and oversight of multiple departments throughout the organization and associated application platform(s) operations, strategy, and technical resourcing globally. This role will identify and influence technology selection, solution approaches, use, and adoption, as well as propose and lead strategic technology initiatives across Karyopharm. Working with peers and Data Management, this role will support the day-to-day delivery needs within the business both with individual contribution as well as associated managed services.

  • Partner with business leaders to identify & prioritize needed business capabilities and create corresponding technology roadmaps

  • Collaborate across IT Business Partners to identify synergies and help establish aggregated technology roadmaps that drive an overall technology vision and optimize the technology footprint

  • Ensure a common architecture is consistent with long-term business objectives by participating in the analysis, evaluation, and development of long-range strategic technology planning.

  • Manage the Regulatory and R&D IT Portfolio, including, but not limited to understanding and managing technical debt, establishing cross-application integration strategies, and ensuring compliance and security through SDLC, as well as, meeting internal and regulatory requirements

  • Oversee application development, implementation, and configuration through a structured project methodologies to successfully deliver internally developed, purchased/customized, and SaaS solutions related

  • Collaborate with IT leadership team to apply best practices in integration and represent Enterprise Applications during envisioning sessions with other IT Groups

  • Establish and implement resource strategies and plans to meet the highest priority demand, allowing for flexibility in capacity (scaling up and down as needed)

  • Develop and manage training strategy and plans to improve team performance

  • Leverage project roadmaps and drive short- and long-term actions to address skills and resource capacity planning

  • Participate in establishing sourcing from 3rd party vendors to create capacity flexibility and scalability. Manage vendors ensuring appropriate measures are in place to monitor and drive vendor performance

  • Drive continuous improvement of KPTI’s business systems to increase effectiveness and efficiency, as well as improve overall internal customer experience.

  • Establish and maintain positive relationships with strategic development partners and with internal business partners

  • Oversee the development of statements of work, contracts, managed service and service level agreements with vendors, and strategic sourcing related to the area of focus

  • Develop and manage effective application and support standards for both IT Operation handoffs and the user community

  • 10+ years of technical biotech/pharma experience with a minimum of 5 years’ leadership/management experience

  • Proven background in effectively planning and executing technology initiatives and/or business process changes

  • Expert knowledge and experience with Veeva Systems, inclusive of but not limited to RIMs, Quality Docs, LMS, and QMS

  • Demonstrated experience with Regulatory and R&D information systems, inclusive of but not limited to eTMF, Argus, SAS, Medidata, and IRT Solutions

  • Demonstrated experience in establishing technology architecture vision and strategies to progress the overall Enterprise IT Application Portfolio to meet the future needs of the business

  • Experience leading large initiatives through the entire life cycle management including requirements gathering and documentation methodologies, application design, vendor selection, development methodologies and project tracking, source control and defect tracking, change management, release control, and documentation, deployment and training

  • Demonstrated ability to influence key business stakeholders on technology decisions

  • Ability to effectively lead/manage stakeholder discussions to reach a desired end goal

  • Ability to explain technical thoughts and ideas to non-technically savvy people

  • Ability to connect business needs to technical solutions as well as alignment to existing and new processes.

  • Reads situations quickly and adjusts approach as needed to have productive discussions

  • Strong understanding of the relationship between applications, databases, operating systems, processing platforms, storage platforms, and networks

  • Proven ability to manage third-party vendor and partner relationships

Karyopharm Therapeutics Inc. (NASDAQ: KPTI) is a commercial-stage pharmaceutical company pioneering novel cancer therapies and dedicated to the discovery, development, and commercialization of first-in-class drugs directed against nuclear export for the treatment of cancer and other diseases. Karyopharm's Selective Inhibitor of Nuclear Export (SINE) compounds function by binding with and inhibiting the nuclear export protein XPO1 (or CRM1). Karyopharm's lead compound, XPOVIO® (selinexor), is approved in the U.S. in multiple hematologic malignancy indications, including in combination with Velcade® (bortezomib) and dexamethasone for the treatment of adult patients with multiple myeloma after at least one prior therapy, in combination with dexamethasone for the treatment of adult patients with heavily pretreated multiple myeloma and as a monotherapy for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma. NEXPOVIO® (selinexor) has also been granted conditional marketing authorization in combination with dexamethasone for adult patients with heavily pretreated multiple myeloma by the European Commission. In addition to single-agent and combination activity against a variety of human cancers, SINE compounds have also shown biological activity in models of neurodegeneration, inflammation, autoimmune disease, certain viruses and wound-healing. Karyopharm has several investigational programs in clinical or preclinical development. For more information, please visit

Karyopharm Therapeutics Inc. (the "Company") is an equal opportunity employer. All qualified applicants will be considered without regard to age, race, color, sex, religion/creed, national origin, marital status, ancestry, citizenship, military, reservist or veteran status, pregnancy, sexual orientation or preference, gender identity, gender expression, physical or mentaldisability, genetic predisposition or carrier status, or any other category protected under applicable federal, state or local law. Consistent with its obligations under applicable law, the Company will make reasonable accommodations for qualified individuals with disabilities. If you require an accommodation in the application process, please contact a member of the Company’s Human

ID: 2021-1867

Street: 85 Wells Ave.